Post-Doctoral Scientist – Mechanistic Modeling & Simulation(SMDD)

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

As part of Lilly Research Laboratories, Synthetic Molecule Design and Development (SMDD) is a dynamic group made up of synthetic chemists, pharmaceutical scientists, analytical chemists, and engineers. We strive to identify, develop and apply groundbreaking technologies to deliver maximum benefit to our patients. Our team is looking for a creative and energetic chemical engineer to collaborate with a growing multidisciplinary team. Aided with high-throughput experimentation and predictive thermodynamic tools, the engineer will use mechanistic modeling to develop a workflow to perform in-silico optimization of the biocatalytic assembly of oligonucleotides.

Responsibilities: Traditionally, oligonucleotide therapeutics such as siRNA, ASO, and sgRNA rely on linear solid-phase oligonucleotide synthesis (SPOS), which is subject to yield, purity, and purification burden challenges as the sequence length increases. In contrast, a promising alternative is a convergent route where shorter oligonucleotide fragments are prepared via SPOS and joined together enzymatically. This enzymatic ligation (EL) approach has demonstrated superior yield, purity, and control of critical impurities as well as reduced environmental impact compared to SPOS. As a result, this approach has generated significant interest from the pharmaceutical industry as exemplified by numerous patents, publications, and conference presentations. Whereas the elementary steps of the ligation reaction have been elucidated in the literature using wild type enzymes, much more is to be understood to enable the development of a scalable and versatile synthesis platform that gets genetic medicines to patients faster.

This postdoctoral position offers the opportunity to build a predictive mechanistic model of enzymatic ligation kinetics, generate process understanding that has previously been limited to qualitative trends, and accelerate EL process development. This project will also leverage high-throughput experimentation capabilities at the Lilly Seaport Innovation Center in Boston to parameterize thermodynamic and kinetic models of oligonucleotide assembly and ligation. The project provides the chance to collaborate not just within SMDD, but also discovery and development teams on multiple genetic medicine modalities across Boston and Indianapolis sites.

The prestigious Lilly Research Laboratories (LRL) post-doctoral program funds challenging and innovative projects in the pre-competitive space with the expectation of external publication and presentation. LRL post docs receive mentorship from leading scientists at Lilly as well as the opportunity to network with other scientists in the program. The post-doc project is expected to result in scientific publications as well as computational workflows for internal process development.

Top candidates for this position will be expected to:

Initiate collaborations across and beyond the SMDD organization to pioneer a multi-disciplinary approach to accelerating process optimization via computational tools

Understand and prioritize key challenges in process development via interactions with diverse talent across the larger organization.

Demonstrate independence, self-motivation, and high learning agility regarding grasping and exploiting new scientific concepts and methods.

Engage the external environment through presentation of findings at conferences and publishing in high-quality peer-reviewed journals.

Embrace diversity of thought, background and experience to deliver innovative solutions. Possess strong communication (oral, written), organizational, and leadership skills.

Apply the scientific method through ambiguity, welcome and rapidly adjust to change, and identify and drive superior methods to accomplish tasks.

Basic Requirements:

PhD in chemical engineering, chemistry, or a related field with experience in modeling and simulation

Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Skills/Preferences:

Experience with biocatalytic reaction systems and their kinetic modeling

Proficiency in programming and modeling and simulation tools (e.g. MATLAB, Python)

Familiarity with nucleic acid structure/thermodynamics prediction tools

Experience with lab automation and high-throughput experimentation

Interpersonal and collaborative skills

Ability to prioritize multiple activities and handle ambiguity

Ability to influence others to promote a positive work environment

Understanding and awareness of the external scientific and regulatory landscape

Demonstrated technical proficiency and ability to create ideas for future work plans

Established external publication record

Additional Information:

Travel: 0 to 10%

Position Location: Lilly Seaport Innovation Center, Boston, MA.

This position is not permanent. It is for a fixed term position up to a maximum of 3 years. Qualified applicants must be authorized to work in the United States on a full-time basis.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$58,000 - $123,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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