Scientist I, Multispecifics Engineering

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

The Multispecifics Engineering group at AbbVie is seeking a highly motivated research scientist to join a dynamic team supporting biologics drug discovery and multispecifics engineering. This position will impact projects through the design and production of biopharmaceutical products. The ideal candidate should have strong experience with multispecifics production and characterization. Other desirable skills include experience with antibody engineering, protein expression and purification expertise, and sequence analysis tools. The applicant should be able to analyze, document, and report data. She/he should possess excellent communication skills and be comfortable presenting in group settings.

Key responsibilities:

Maintain mammalian cell lines and optimize conditions

Design multispecifics for production

Prep DNA, express, and purify multispecific biologics to meet project team needs

Help maintain DNA and protein inventory for group

Prepare aliquots and plates for various assay and project teams and coordinate handoffs

Generate production reports and keep lab notebooks up to date

Present data at project team meetings and at internal meetings or conferences

Qualifications

BS or MS in biology or related field with 5+ years (BS), or 2+ years (MS) of pharmaceutical and/or relevant experience

Experience with bacterial and mammalian cell culture

Experience with protein, biologics, fragments, and multi-specifics purification

Experience with SEC, HIC, IEX purification utilizing AKTAs

Experience with in vitro analytical techniques for protein characterization (e.g. SEC, MS, DSF)

Experience with plasmid prep, molecular cloning

Excellent oral and written communication skills

Excellent organization skills and the ability to execute on multiple projects simultaneously

Team player with the ability to operate in a fast-paced multi-disciplinary environment

Adapt to rapid changes in project priorities and timelines

Competency with software programs, including MS Excel, Powerpoint, Word

Preferred Qualifications:

Experience operating automation equipment (e.g. Hamilton, AssayMap, Kingfisher) in biologics discovery processes

Experience with setup and management of biologics and DNA inventory systems such as Freezerpro

CHO expression experience including optimizing conditions and plasmid ratios for multispecifics

Experience with ELISA, FACS

Expereince with mass spectrometry interpretation for complex biologics

Experience with the software programs Geneious, Genedata, PMI, and Unicorn

Experience with CRO coordination

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount isearned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits thatare allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole andabsolute discretion, consistent with applicable law.

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