Core Facility Manager (Transgenic & Gene Targeting)

Job Title: Core Facility Manager (Transgenic & Gene Targeting)

University-Level Unit: Cancer Science Institute of Singapore

Faculty/Department-Level Unit: Cancer Science Institute of Singapore

Employee Category: Research Staff

Location_ONB: Kent Ridge Campus

Posting Start Date: 20/02/2026

Job Description

The Head of the Transgenic Mouse Facility provides scientific, operational, and strategic leadership for an institutional core facility supporting the generation, breeding, and management of genetically engineered mouse models. This role oversees facility operations, staff, technology platforms, and compliance, while partnering closely with investigators to enable high-quality, reproducible research.

This position operates in a laboratory and animal facility setting and requires adherence to institutional safety and animal care policies.

Duties And Responsibilities

Scientific & Technical Leadership

Lead the design, implementation, and optimization of transgenic and genome-editing technologies (e.g., CRISPR/Cas9, ES cell targeting, conditional alleles).

Direct rederivation services (e.g., embryo transfer, IVF-based rederivation) to ensure colony health and biosecurity.

Oversee sperm and embryo cryopreservation services, including experimental design, execution, quality control, and recovery validation.

Provide expert consultation to investigators on experimental design, feasibility, timelines, and model selection.

Stay current with emerging technologies and drive continuous improvement of facility capabilities.

Facility & Operations Management

Direct day-to-day operations of the transgenic mouse facility, including scheduling, workflow optimization, and resource allocation.

Oversee colony management strategies in coordination with animal care and veterinary teams at CM.

Oversee a centralized cryobank, including inventory control, database management, labelling, storage integrity, and disaster recovery planning.

Develop and enforce SOPs for cryopreservation, thawing, reanimation, and long-term storage.

Develop and manage facility budgets, pricing, and capital equipment planning.

Establish and maintain SOPs to ensure efficiency, quality, and reproducibility.

Financial Management & Cost Recovery

Develop and manage facility budgets, recharge rates, and service pricing.

Oversee the collection of annual cryostorage fees for sperm and embryo samples and ensure transparent communication of costs and policies to investigators.

Monitor cost recovery, utilization metrics, and long-term financial sustainability of the facility and cryobank operations.

Participate in capital planning for specialized equipment and infrastructure.

Personnel Management

Recruit, train, supervise, and mentor facility staff, promoting technical excellence and a collaborative culture.

Ensure staff proficiency in advanced reproductive technologies, cryopreservation methods, and regulatory compliance.

Conduct performance evaluations and support professional development.

Compliance & Quality Assurance

Ensure full compliance with institutional, local, and federal regulations (IACUC, AAALAC, animal welfare standards).

Maintain accurate records for transgenic production, rederivation, cryopreservation, and storage activities.

Collaborate with veterinary, compliance, and biosafety teams to maintain high standards of animal health and data integrity.

Collaboration & Institutional Engagement

Serve as a key liaison between the facility and the research community.

Contribute to grant applications, publications, and institutional initiatives involving mouse model development.

Participate in strategic planning for core facilities and research infrastructure.

Any Other Duties:

Perform other job-related duties as assigned

Qualifications

Required Qualifications

PhD, DVM, or equivalent advanced degree in genetics, molecular biology, biomedical sciences, or a related field.

At least 6 years hands-on experience with transgenic mouse generation and genome editing technologies.

Demonstrated experience managing a research facility, laboratory, or core service.

Strong knowledge of mouse genetics, breeding strategies, and colony management.

Proven leadership, communication, and organizational skills.

Preferred Qualifications

Experience leading a transgenic or genome engineering core facility.

Familiarity with cost-recovery models and core facility financial management.

Track record of collaboration with diverse research groups.

Experience in an academic medical center or research institute environment.