Sr Scientist/Principal Scientist - Genomics Sciences

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Job Description:

The Genomic Sciences team within Lilly Genetic Medicine/RNA Therapeutics is seeking a senior experimental genomics expert to lead and execute genomics assays in support of the discovery and development of RNA medicines. This role is embedded in a high-throughput genomics screening environment that generates decisional data for siRNA and antisense oligonucleotide programs across the LGM portfolio. The successful candidate will be a hands-on experimentalist with strong technical skills in next-generation sequencing (NGS), a commitment to rigorous sample management and documentation, and a desire to contribute meaningfully to the advancement of genetic medicines.

Key Responsibilities:

Execute and optimize NGS library preparation workflows (e.g., 3’ RNA-seq, mRNA-seq, etc.) across targeted and large-scale screening campaigns, maintaining high quality and throughput

Track, document, and QC samples through all stages of assay development

Develop, troubleshoot, and refine genomics assay protocols to meet evolving program needs, including new library chemistries, multiplexing strategies, and sample input optimization

Maintain impeccable sample tracking, chain-of-custody documentation, and electronic lab notebook records in compliance with Lilly quality standards

Collaborate closely with computational genomics, medicinal chemistry, and biology colleagues to ensure experimental designs generate robust, interpretable, and decisional data

Participate actively in cross-functional project teams, contributing scientific perspective on assay design, data interpretation, and experimental prioritization

Support lab infrastructure including reagent inventory, equipment maintenance, and continuous improvement of standard operating procedures

Basic Qualifications:

Bachelor’s degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 3+ years of relevant laboratory experience; OR Master’s degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 1+ years of relevant laboratory experience

Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Preferred Qualifications:

Demonstrated hands-on experience with NGS library preparation, quality control (Qubit, TapeStation/Bioanalyzer, qPCR-based quantification), and sequencer operation

Strong organizational skills with meticulous attention to sample management, documentation, and experimental reproducibility

Ability to work effectively in a fast-paced, team-oriented research environment generating high-quality decisional data at scale

Experience with high-throughput or pooled screening workflows in a pharmaceutical or genomics core environment

Experience with singe cell genomics or spatial transcriptomics data

Familiarity with RNA therapeutics biology (siRNA, ASO) and associated transcriptomic readouts

Bioinformatics experience including comfort with command-line tools, scripting (R, Python), and/or analysis of NGS data (alignment, QC metrics, differential expression)

Experience with automation platforms (e.g., Hamilton, Beckman) for library preparation or sample handling

Track record of method development or assay optimization in a research or development setting

Experience using and developing ELN based documentation tools.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$71,250 - $187,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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