Principal Scientist, Analytical Sciences

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Orna Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company, is an innovative biotechnology startup based in Watertown, MA, committed to developing groundbreaking therapies for diseases that current approaches cannot address. With our pioneering circular RNA technology, developed at MIT, we are at the forefront of advancing the next generation of RNA therapeutics. Our state-of-the-art expression and delivery platform positions us to tackle complex diseases, including B cell-driven autoimmune disorders, B cell malignancies, sickle cell disease, and beyond.

Position Summary:

We are seeking an exceptional Principal Scientist, Analytical Sciences, to join our Analytical Sciences team to run analytical methods for the characterization of RNA therapeutics. The ideal candidate is a motivated individual that can execute chromatography experiments with efficiency and creativity. They should have relevant analytical development experience, possess strong oral and written communication capabilities, demonstrate excellent collaboration & interpersonal skills, and be adept at problem solving in a fast-paced environment.

Responsibilities:

Implement Orna’s analytical testing strategy for circular RNA and lipid nanoparticle formulations with a focus on chromatography methods.

Develop and qualify drug substance and drug product analytical methods and perform characterization studies.

Build and develop internal analytical capabilities to support in-process, release, stability, and characterization testing of drug products.

Perform regular maintenance on HPLCs and other laboratory instrumentation.

Maintain a clean and safe laboratory environment.

Support method transfers to Contract Research Organizations and provide technical guidance/troubleshooting.

Review method procedures, method validation protocols, and reports.

Generate, interpret, and present data to cross-functional R&D teams.

Contribute to a positive and exciting work environment and a strong entrepreneurial and creative culture.

Basic Requirements:

BS degree in analytical chemistry, biochemistry, or a similar area, with 6-9 years of relevant experience in analytical method development

Or MS degree in analytical chemistry, biochemistry, or a similar area with 3+ years of relevant experience in analytical method development

Experience with HPLC/UPLC and related software is required.

Experience with development, qualification, validation, and transfer of analytical methods in a GxP environment to support process development, product characterization, release, stability studies, and other analytical studies.

Additional Preferences:

IP-RP, SEC, and AEX are particularly valued. Knowledge of additional analytical methodologies such as LC-MS, DLS, CE, and/or Spectrophotometry and regulatory requirements is a plus.

Experience with LNPs and/or mRNA is highly desirable.

Strong oral and written skills and the ability to work independently with minimal support.

Additional Information:

Physical Demands/Travel:

The physical demands of this job are consistent with lab environment.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a laboratory environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$71,250 - $187,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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