Senior Clinical Trial Manager

Senior Clinical Trial Manager - Remote - Brazil

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

The Senior Clinical Trial Manager (Senior CTM) is responsible for the end-to-end operational oversight of assigned clinical trials, ensuring delivery against agreed timelines, budget, and quality standards. This includes oversight of site management (remote and onsite), clinical team activities, and compliance with regulatory requirements.

The Senior CTM leads Clinical Operations execution and serves as the primary point of accountability for trial delivery, working cross-functionally with internal teams and externally with sponsors.

What you will do:

Trial Execution & Oversight

Plan and manage all clinical operations activities across assigned trials.

Ensure delivery in line with scope, timelines, budget, and quality expectations.

Oversee global site lifecycle activities, including start-up, activation, monitoring, and close-out.

Team Leadership & Oversight

Lead and oversee project specific operational activities of Clinical Research Associates (CRAs) and Site Management Associates (SMAs).

Provide direction, training, and study performance oversight for clinical team members.

Review monitoring reports, documentation, and study deliverables for quality and compliance.

May act as a mentor to study assigned CRAs, SMAs, and/or other department CTMs.

Site & Monitoring Management

Develop and implement site management and monitoring plans.

Oversee remote and onsite monitoring activities, including visit planning and execution.

Ensure timely collection, review, and maintenance of trial documentation in CTMS.

Risk & Quality Management

Proactively identify risks and implement mitigation strategies.

Utilize metrics and dashboards to monitor study performance and quality.

Support data review and query management activities as needed.

Stakeholder Management

Collaborate with cross-functional teams (Project Management, Data Management, Finance).

Build and maintain strong relationships with sponsors and external partners.

Provide status updates, metrics, and key study insights to stakeholders.

Compliance & Governance

Ensure adherence to ICH-GCP, regulatory requirements, and internal SOPs.

Support audit and inspection readiness.

Additional Contributions

Participate in bid defense activities as required.

Contribute to department initiatives, process improvements and operational best practices.

What you need?

Bachelor’s degree in life sciences or related field (or equivalent experience) with at least 3+ years of experience in a CTM or equivalent role (CRO or pharmaceutical environment)

Experience managing Phase III and/or IV clinical trials across multiple therapeutic areas.

Knowledge of risk-based monitoring (RBM) principles preferred

Experience managing complex and/or global trials

Experience managing studies from start-up through database lock

Experience coaching or mentoring CTMs, leading teams, and participating in departmental initiatives

Ability to manage multiple studies and priorities in a fast-paced environment

Strong leadership, organizational, and problem-solving skills

Effective communication and stakeholder management skills

Willingness to travel (~15%)

Key Competencies

Leadership and team management

Strategic planning and execution

Risk assessment and mitigation

Decision-making and problem-solving

Cross-functional collaboration

Communication and stakeholder engagement

#LI-Remote

#LI-AR1

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits may include:

Competitive base salary and performance related incentives

Health and wellbeing programmes including medical, dental, and vision coverage where applicable

Retirement and pension plans

Life assurance and disability coverage

Employee assistance programmes and wellbeing resources

Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

Visit our careers site to about the benefits ICON offers.

Inclusion and Accessibility

If you require reasonable accommodations during the recruitment process, please let us know or submit a request here.