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Staff Software Engineer, Full Stack - Early Cancer Detection (ECD)

Natera

us, USonsite$167k-$209k/yrPosted May 26, 2026

At a glance

Highlights

  • Competitive benefits package
  • Free employee genetic testing
  • Fertility care benefits
  • Generous employee referral program

Heads up

  • 10+ years experience required
  • Regular on-site lab visits required

Why this role might suit you

The position enables a senior engineer to lead high‑impact backend services for Natera’s Early Cancer Detection program, work with scalable AWS infrastructure, and shape product strategy while mentoring junior staff.

Skills

typescriptpythongitlabci-cdunit-testingapi-testingintegration-testingawsinfrastructure-as-codekafkaagent-drivenroot-cause-analysis

About the role

POSITION SUMMARY:

We are seeking an experienced Staff Software Engineer, Backend (or Full Stack), for our Early Cancer Detection (ECD) program, who excels at collaboratively solving complex problems. If you take ownership of your work, think strategically, and have a proven track record of implementing solutions while adapting to constraints and minimizing risks, we encourage you to apply. Strong technical expertise, excellent communication skills, and a desire to thrive in a dynamic environment are essential. In this role, you will collaborate closely with our Engineering Team, Product Managers, and Designers to develop innovative experiences for our internal stakeholders, primarily focusing on creating a custom lab software solution for a high-throughput laboratory.

PRIMARY RESPONSIBILITIES

Design, develop, and maintain scalable services that support the diverse activities of a high-throughput laboratory.

Develop back-end applications that interact with other software.

Implement and manage CI/CD pipelines using GitLab.

Develop comprehensive tests (unit, api, integration) to ensure high code quality.

Collaborate closely with end-users and product managers to iterate on requirements and deliverables.

Optimize architecture and infrastructure on the AWS cloud platform for performance, scalability, reliability, and cost-effectiveness.

Proactively monitor system performance, troubleshoot issues, conduct thorough root cause analysis, and implement enhancements to improve efficiency and reliability.

Stay current with emerging technologies and best practices in software engineering and actively contribute to continuous improvement initiatives.

Be the technical lead and mentor more junior engineers.

QUALIFICATIONS

BS degree in computer science, comparable program, or equivalent.

10+ years of full stack software development experience.

Proven experience with programming languages such as TypeScript (preferred), or Python

Experience with software development lifecycle process from build, software configuration, change control, and release and deployment activities.

Strong quality assurance mindset with a commitment to delivering robust and reliable software.

Proficiency in messaging frameworks such as Kafka.

Proficiency in infrastructure as code (IaC).

Excellent problem-solving skills and the ability to work both independently and collaboratively in a dynamic environment.

Excellent use of modern Agent-Driven development practices.

Strong written and verbal communication skills, coupled with excellent interpersonal skills enabling effective interaction with stakeholders at all levels.

NICE TO HAVE

Experience working in highly regulated environments.

Able to visit the lab in San Carlos, CA on a regular basis to facilitate direct observation of the software in the lab and obtain real-time user feedback.

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

Annual performance incentive bonus

Long-term equity awards

Comprehensive health benefits (medical, dental, vision)

401(k) with company match

Generous paid time off and company holidays

Additional wellness and work-life benefits

Compensation Range

$167,300 - $209,100 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

Compensation

This Full-Stack Engineer role pays $167k-$209k/yr. Within typical range for full-stack engineer roles in United States.

Questions about this role

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